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Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease
Mann AP, Scodeller P, Hussain S, Braun GB, Mölder T, Toome K, Ambasudhan R, Teesalu T, Lipton SA, Ruoslahti E.
Nat Commun. 2017 Nov 10;8(1):1403. doi: 10.1038/s41467-017-01096-0.
Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide
Scodeller P, Simón-Gracia L, Kopanchuk S, Tobi A, Kilk K, Säälik P, Kurm K, Squadrito ML, Kotamraju VR, Rinken A, De Palma M, Ruoslahti E, Teesalu T.
Sci Rep. 2017 Nov 7;7(1):14655. doi: 10.1038/s41598-017-14709-x.
Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy
Cureton N, Korotkova I, Baker B, Greenwood S, Wareing M, Kotamraju VR, Teesalu T, Cellesi F, Tirelli N, Ruoslahti E, Aplin JD, Harris LK.
Theranostics. 2017 Aug 29;7(15):3715-3731. doi: 10.7150/thno.19678. eCollection 2017.
Vascular changes in tumors resistant to a vascular disrupting nanoparticle treatment.
Sharma S, Mann AP, Mölder T, Kotamraju VR, Mattrey R, Teesalu T, Ruoslahti E.
J Control Release. 2017 Oct 13;268:49-56. doi: 10.1016/j.jconrel.2017.10.006. [Epub ahead of print]
Targeting of p32 in peritoneal carcinomatosis with intraperitoneal linTT1 peptide-guided pro-apoptotic nanoparticles
Hunt H, Simón-Gracia L, Tobi A, Kotamraju VR, Sharma S, Nigul M, Sugahara KN, Ruoslahti E, Teesalu T.
J Control Release. 2017 Aug 28;260:142-153. doi: 10.1016/j.jconrel.2017.06.005. Epub 2017 Jun 8.
Ratiometric in vivo auditioning of targeted silver nanoparticles
Toome K, Willmore AA; Paiste P, Tobi A, Sugahara KN, Kirsimäe K, Ruoslahti E, Braun GB, Teesalu T.
Nanoscale. 2017 Jul 20;9(28):10094-10100. doi: 10.1039/c7nr04056c.
Hyaluronan-binding peptide for targeting peritoneal carcinomatosis
Ikemoto H, Lingasamy P, Anton Willmore AM, Hunt H, Kurm K, Tammik O, Scodeller P, Simón-Gracia L, Kotamraju VR, Lowy AM, Sugahara KN, Teesalu T.
Tumour Biol. 2017 May;39(5):1010428317701628. doi: 10.1177/1010428317701628.
Tumor-Penetrating Nanosystem Strongly Suppresses Breast Tumor Growth
Sharma S, Kotamraju VR, Mölder T, Tobi A, Teesalu T, Ruoslahti E.
Nano Lett. 2017 Mar 8;17(3):1356-1364. doi: 10.1021/acs.nanolett.6b03815. Epub 2017 Feb 17.
iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes
Simon-Gracia L, Hunt H, Scodeller P, Gaitzsch J, Kotamraju VR, Sugahara KN, Tammik O, Ruoslahti E, Battaglia G,Teesalu T
Biomaterials. 2016 Jul 20;104:247-257. doi: 10.1016/j.biomaterials.2016.07.023. [Epub ahead of print]
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries
Aman P. Mann, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Ester Kwon, Gary B. Braun, Tarmo Mölder, Zhi-gang She, Venkata Ramana Kotamraju, Barbara Ranscht, Stan rajewski, Tambet Teesalu, Sangeeta Bhatia, Michael J. Sailor, Erkki Ruoslahti.
Nature Communications 7, Article number: 11980, doi: 10.1038/ncomms11980
Tumor-homing peptides as tools for targeted delivery of payloads to the placenta
King A, Ndifon C, Lui S, Widdows K, Kotamraju VR, Agemy L, Teesalu T, Glazier JD, Cellesi F, Tireli N, Aplin JD, Ruoslahti E, Harris LK.
Science Advances 06 May 2016: Vol. 2, no. 5, e1600349 DOI: 10.1126/sciadv.1600349
Paclitaxel-loaded Polymersomes for Enhanced Intraperitoneal Chemotherapy
Simón-Gracia L,Hunt H, Scodeller PD, Gaitzsch J, Braun GB, Willmore AA, Ruoslahti E, Battaglia G, Teesalu T
Mol Cancer Ther. 2016 Feb 15. pii:molcanther.0713.2015 [Epub ahead of print]
Urokinase-controlled tumor penetrating peptide
Braun GB, Sugahara KN, Yu OM, Kotamraju VR, Mölder T, Lowy AM, Ruoslahti E, Teesalu T
J Control Release. 2016 Apr 19. pii: S0168-3659(16)30240-1. doi: 10.1016/j.jconrel.2016.04.027. [Epub ahead of print]
New p32/gC1qR Ligands for Targeted Tumor Drug Delivery
Paasonen L,Sharma S, Braun GB, Kotamraju VR, Chung TD, She ZG, Sugahara KN, Yliperttula M, Wu B, Pellecchia M, Ruoslahti E, Teesalu T
Chembiochem. 2016 Feb 19. doi: 10.1002/cbic.201500564. [Epub ahead of print]
Targeted silver nanoparticles for ratiometric cell phenotyping.
Willmore AA, Simón-Gracia L, Toome K, Paiste P, Kotamraju VR, Mölder T, Sugahara KN, Ruoslahti E, Vraun GB, Teesalu T
Nanoscale. 2015 Dec 8. [Epub ahead of pront]
Ultrasound molecular imaging of tumor angiogenesis with a neuropilin-1-targeted microbubble.
Zhang H, Tam S, Ingham ES, Mahakian LM, Lai CY, Tumbale SK, Teesalu T, Hubbard NE, Borowsky AD, Ferrara KW
Biomaterials. 2015 Jul;56:104-13. doi: 10.1016/j.biomaterials.2015.03.043. Epub 2015 Apr 16.
A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis
Sugahara KN, Scodeller P, Braun GB, de mendoza TH, Yamazaki CM, luger MD, Kitayama J, Alvarez E, Howell SB, Teesalu T, Ruoslahti E, Lowy AM
J Control Release. 2015 Jun 11;212:59-69. doi: 10.1016/j.jconrel.2015.06.009. [Epub ahead of print]
An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability
Pang HB, Braun GB, Friman T, Aza-Blanc P, Ruidiaz ME, Sugahara KN, Teesalu T, Ruoslahti E.
Nat Commun. 2014 Oct 3;5:4904. doi: 10.1038/ncomms5904.
Tumor-Penetrating iRGD Peptide Inhibits Metastasis
Sugahara KN, Braun GB, de Mendoza TH, Kotamraju VR, French RP, Lowy AM, Teesalu T, Ruoslahti E.
Mol Cancer Ther. 2015 Jan;14(1):120-8. doi: 10.1158/1535-7163.MCT-14-0366. Epub 2014 Nov 12.
Reprogramming Human Retinal Pigmented Epithelial Cells to Neurons Using Recombinant Proteins
Hu Q, Chen R, Teesalu T, Ruoslahti E, Clegg DO.
Stem Cells Transl Med. 2014 Oct 8. pii: sctm.2014-0038.
Etchable plasmonic nanoparticle probes to image and quantify cellular internalization
Braun GB, Friman T, Pang HB, Pallaoro A, de Mendoza TH, Willmore AM, Kotamraju VR, Mann AP, She ZG, Sugahara KN, Reich NO, Teesalu T, Ruoslahti E.
Nat Mater. 2014 Jun 8. doi: 10.1038/nmat3982.
A free cysteine prolongs the half-life of a homing peptide and improves its tumor-penetrating activity
Hong-Bo Pang, Gary B. Braun, Zhi-Gang She, Venkata R. Kotamraju, Kazuki N. Sugahara, Tambet Teesalu, Erkki Ruoslahti
J Control Release. 2014 Feb 10;175:48-53. doi: 10.1016/j.jconrel.2013.12.006. Epub 2013 Dec 15.
Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies
Sánchez-Martín D, Martínez-Torrecuadrada J, Teesalu T, Sugahara KN, Alvarez-Cienfuegos A, Ximénez-Embún P, Fernández-Periáñez R, Martín MT, Molina-Privado I, Ruppen-Cañás I, Blanco-Toribio A, Cañamero M, Cuesta AM, Compte M, Kremer L, Bellas C, Alonso-Camino V, Guijarro-Muñoz I, Sanz L, Ruoslahti E, Alvarez-Vallina L
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13791-6. doi: 10.1073/pnas.1300013110. Epub 2013 Aug 5
Tumor-penetrating peptides
Teesalu T, Sugahara KN, Ruoslahti E
Front. Oncol., 27 August 2013 | doi: 10.3389/fonc.2013.00216
Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor
Zanuy D, Kotla R, Nussinov R, Teesalu T, Sugahara KN, Alemán C, Haspel N.
J Struct Biol. 2013 Feb 24. doi:pii: S1047-8477(13)00043-9. 10.1016/j.jsb.2013.02.006. [Epub ahead of print]
The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles
Missirlis D, Teesalu T, Black M, Tirrell M.
PLoS One. 2013;8(1):e54611. doi: 10.1371/journal.pone.0054611. Epub 2013 Jan 17.
Application of a proapoptotic peptide to intratumorally spreading cancer therapy
Chen R, Braun GB, Luo X, Sugahara KN, Teesalu T, Ruoslahti E.
Cancer Res. 2013 Feb 15;73(4):1352-61. doi: 10.1158/0008-5472.CAN-12-1979. Epub 2012 Dec 17.
De novo design of a tumor-penetrating peptide
Alberici L, Roth L, Sugahara KN, Agemy L, Kotamraju VR, Teesalu T, Bordignon C, Traversari C, Rizzardi GP, Ruoslahti E.
Cancer Res. 2013 Jan 15;73(2):804-12. doi: 10.1158/0008-5472.CAN-12-1668. Epub 2012 Nov 14.
Mapping of vascular ZIP codes by phage display
Teesalu T, Sugahara KN, Ruoslahti E.
Methods Enzymol. 2012;503:35-56. doi: 10.1016/B978-0-12-396962-0.00002-1.
