The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
LinTT1 tumor penetrating peptide guided nanoparticles for improved imaging and therapy of glioblastoma
Written on Wednesday, 03 July 2019 15:55In a collaborative study “Peptide-guided nanoparticles for glioblastoma targeting” published in Journal of Controlled Release we evaluated a novel tumor penetrating peptide that targets cell…
Prof. Tambet Teesalu gave an inaugural lecture entitled “Nanomedicine: big opportunities in a small world”
Written on Monday, 20 May 2019 15:31Prof. Tambet Teesalu gave an inaugural lecture entitled “Nanomedicine: big opportunities in a small world” in the main hall of the University of Tartu on…
Congratulations to Hedi Hunt for successfully defending her PhD thesis!
Written on Friday, 03 May 2019 09:22Hedi Hunt successfully defended her Ph.D. thesis "Precision targeting of intraperitoneal tumors with peptide-guided nanocarriers" on April 18th, 2019. Her thesis dealt with the development…
Peptide-guided nanoparticles for glioblastoma targeting
Written on Wednesday, 03 July 2019 15:50Säälik P, Lingasamy P, Toome K, Mastandrea I, Rousso-Noori L, Tobi A, Simón-Gracia L, Hunt H, Paiste P, Kotamraju VR, Bergers G, Asser T, Rätsep…Read more...
IGF signalling and endocytosis in the human villous placenta in early pregnancy as revealed by comparing quantum dot conjugates with a soluble ligand
Written on Wednesday, 03 July 2019 15:48Karolczak-Bayatti M, Forbes K, Horn J, Teesalu T, Harris LK, Westwood M, Aplin JD. Nanoscale. 2019 Jun 27;11(25):12285-12295. doi: 10.1039/c8nr10337b.Read more...
OctoberPeptide targeted polymersomes bind to M2 human macrophagesPolymersomes targeted with an M2 macrophage binding peptide (green) identified in our lab using phage display bind to and are taken up by M2s (red) originated from human primary monocytes.…
SeptemberPolymersomes targeted with an M2 macrophage binding peptide in a mouse model of triple negative breast cancerPolymersomes targeted with an M2 macrophage binding peptide (green) identified in our lab using phage display home to M2 TAMs (red) after intravenous administration in a mouse model of triple…
JanuaryHigh infiltration of CD206+ cells in human breast tumorsImmunohistochemical staining of human CD206 (brown) with nuclear counterstain (Hematoxilin, in dark blue). Authors: Anni Lepland and Pablo Scodeller.