The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
Dr. Teesalu has given a series of invited talks on international conferences in Europe and in the US
Written on Tuesday, 16 October 2018 10:31Dr. Teesalu has given a series of invited talks on international conferences in Europe and in the US: The 4th Brain Tumors Conference 2018: From…
New nanoparticles for detection of small breast tumors with PET imaging reported in Oncotarget
Written on Thursday, 24 May 2018 12:52We have designed new nanoparticles that detect small breast tumors using the clinically used medical imaging modality Positron Emission Tomography (PET). The particles are polymeric…
Tambet Teesalu’s translational work recognized by the University of Tartu
Written on Thursday, 24 May 2018 12:50The translational work at the Lab of Cancer Biology in 2017 was recognized by University of Tartu by awarding the head of the laboratory Tambet…
Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides
Written on Thursday, 24 May 2018 14:05Simón-Gracia L, Hunt H, Teesalu T..Molecules. 2018 May 16;23(5). pii: E1190. doi: 10.3390/molecules23051190. Review.Read more...
Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice
Written on Thursday, 24 May 2018 14:02Simón-Gracia L, Scodeller P, Fuentes SS, Vallejo VG, Ríos X, San Sebastián E, Sidorenko V, Di Silvio D, Suck M, De Lorenzi F, Rizzo LY,…Read more...
OctoberPeptide targeted polymersomes bind to M2 human macrophagesPolymersomes targeted with an M2 macrophage binding peptide (green) identified in our lab using phage display bind to and are taken up by M2s (red) originated from human primary monocytes.…
SeptemberPolymersomes targeted with an M2 macrophage binding peptide in a mouse model of triple negative breast cancerPolymersomes targeted with an M2 macrophage binding peptide (green) identified in our lab using phage display home to M2 TAMs (red) after intravenous administration in a mouse model of triple…
JanuaryHigh infiltration of CD206+ cells in human breast tumorsImmunohistochemical staining of human CD206 (brown) with nuclear counterstain (Hematoxilin, in dark blue). Authors: Anni Lepland and Pablo Scodeller.