Prof. Tambet Teesalu presented his  work on discovery and application of tumor homing peptides for targeted delivery of drugs and nanoparticles on the EMBO Young Investigator Program Cancer Group meeting in Marseille, France. 

Participants from left: Anna Sabina, Hacer Ezgi Karakas, Axel Behrens, Pascale Zimmermann, Vita Bryja, Bernd Zeisig, Devrim Gozuacik, Rania Ghossoub, Joanna Fare, Tambet Teesalu, Eric So, Erica Tse (missing: Johanna Ivaska).

Lorena Simón Gracia (left) from the laboratory of Cancer Biology participated in the European Foundation for Clinical Nanomedicine meeting “Paving the way to personalized diagnostics and therapy” (Basel, Switzerland). She presented a poster “Tumor penetrating pH-sensitive polymersomes for cancer theranostics” (authors: Simón L, Hunt H, Madsen J, Kotamraju VR, Braun G, Willmore AM, Ruoslahti E, Battaglia G, Teesalu T). Middle: Pablo Schodeller; right: Gary B Braun  (both from collaborating Ruoslahti lab at Sanford Burnham Medical Research Institute, La Jolla, USA).

Anne-Mari A. Willmore and Tambet Teesalu of the Lab of Cancer Biology were among the members of the team that reported in Nature Materials on the development of etchable plasmonic silver nanoparticle system for cancer targeting studies. The lead author of the study “Etchable plasmonic nanoparticle probes to image and quantify cellular internalization” (http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat3982.html) is Gary B Braun Ph.D. of Sanford Burnham Medical research Institute, La Jolla (USA) –PhD co-supervisor of Anne-Mari A. Willmore.

We are happy to congratulate our enthusiastic and talented M.Sc. students for successful conclusion of their thesis work and wish them good luck in future endeavors!

  Annika Jürimäe: „Identification of long-circulating peptides using in vivo phage display“. The aim of Annika’s work was to identify peptides that increase phage blood half-life and can be used as RES-avoiding peptides on synthetic nanoparticles.

  Kairit Kukk: “In vitro interactions of tumor-penetrating peptides with spontaneous tumours of dogs and cats”. This work characterized ex vivo binding, internalization and penetration of a panel of tumor homing peptides to a panel of spontaneous  veterinary tumors. 

  Vidrik Teder: „Serum ratiometric diagnostic peptide screening using in vivo phage display“. The aim of Vidrik’s  work was to identify peptides that modulate blood clearance of nanoparticles in tumor-dependent manner.

The Lab of Cancer Biology moved to newly built Center for Translational Medicine Building. The center includes a large animal facility and modern laboratories that will facilitate groundbreaking work on developing targeted cancer therapies.
External link: http://news.postimees.ee/2804522/tartu-gets-top-level-translational-medicine-centre

The second joint meeting  with prof. Langel’s lab at Institute of Technology of the University of Tartu  (organizer: Kaido Kurrikoff Ph.D.) was held in Pühajärve hotel in Southern Estonia. Different aspects of peptide-mediated payload delivery, peptide design, and nanotechnology were discussed in 11 talks, followed by a general discussion and social activities. 

Pille Säälik, Tambet Teesalu, and Kadri Toome participated  at the 105th Annual Meeting of the American Association for Cancer Research on April 5-9, 2014 in San Diego, California, USA. The AACR Annual Meeting is the premier cancer research event where the latest and most exciting basic, translational, and clinical discoveries are presented each year. The theme for the AACR Annual Meeting 2014 was, “Harnessing Breakthroughs – Targeting Cures” and it drew over 18,000 researchers, patient advocates, and other professionals in the cancer field from around the world.

The members of the team of Lab of Cancer Biology  were coauthors in the following poster presentations:

1. A tumor-specific tissue penetrating peptide inhibits metastasis. Kazuki N. Sugahara, Gary B. Braun, Tatiana H. De Mendoza, Venkata R. Kotamraju, Tambet Teesalu, Erkki Ruoslahti, Randall P. French, Andrew M. Lowy.
2. Targeting premalignant lesions for early breast cancer detection andAman P. Mann, Ramana Kotamraju, Tambet Teesalu, Erkki Ruoslahti.
3. The CendR pathway: A novel cell penetration and transcytosis pathway regulated by nutrientHong-Bo Pang, Gary B. Braun, Tomas Friman, Pedro Aza-Blanc, Manuel E. Ruidiaz, Kazuki N. Sugahara, Tambet Teesalu, Erkki Ruoslahti.
4. Urokinase plasminogen activator-dependent tumor penetrating peptide. Tambet Teesalu, Kazuki N. Sugahara, Gary B. Braun, Venkata Ramana Kotamraju, Erkki Ruoslahti
5. In vivo audition of tumor homing peptides using high-throughput sequencing and q-PCR. Kadri Toome, Tarmo Mölder, Kuldar Kõiv, Pille Säälik, Kazuki N. Sugahara, Erkki Ruoslahti, Tambet Teesalu.

A review in Frontiers in Oncology by discoverers of the tumor penetrating peptide technology Drs Teesalu, Sugahara, and Ruoslahti summarizes  the discovery, applications, and future perspectives of the TPP for targeted delivery of payloads to tumors.   Front Oncol. 2013 Aug 27;3:216. doi: 10.3389/fonc.2013.00216. PMID: 23986882

Norwegian-Estonian Research Cooperation Programme reached a positive funding decision regarding the joint proposal of the lab of Cancer Biology  with the group of Prof. Bjerkvig in the University of Bergen (Norway) on the development of glioma stem cell like cell targeting peptides. The project is one out of 13 projects (170 total) that  were  recommended for funding.

Prof. Tambet Teesalu presented his work on the P32 binding tumor penetrating peptide and on the development of the high-throughput sequencing-based phage display platform  on the EMBO Young Investigator Program Cancer Group meeting in Antalya, Turkey.