The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.

We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.

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Recent publications

Images

  • May

    Hollow gold-silver nanospheres Hollow gold-silver nanospheres
    Hollow gold-silver nanospheres imaged with a TEM at 160 000x magnification. Author: Anne-Mari Anton Willmore, MSc
  • April

    The "UNO" peptide recognizes​ circulating​ tumor​ associated​​ macrophages The "UNO" peptide recognizes​ circulating​ tumor​ associated​​ macrophages
    Mouse model of metastatic human gastric cancer, MKN45-P. Microscope: Olympus FV1200MPE-BX61WI confocal microscope at 20X magnification Green: peptide, Red: tumor associated macrophages, blue: cell nuclei. Author: Pablo Scodeller, PhD
  • March

    TT1-FAM-IONW TT1-FAM-IONW
    WT GBM intracranial glioma-bearing mouse was injected with 7,5 mg /kg TT1-FAM-iron oxide nanoworms. After 5 hours of circulation the mouse was perfused and FAM fluorescence was detected by illumatool.…