The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
Targeted nanosystems for imaging and therapy Spring workshop, Tartu, Estonia, May 10-12, 2017
Written on Thursday, 06 April 2017 15:58This workshop provides an opportunity to get an overview of translational nanobiomedicine research from the leading European experts. The overarching themes are interactions of nanoparticles…
iRGD-targeted polymersomes for enhanced intraperitoneal chemotherapy
Written on Tuesday, 09 August 2016 09:36We report in Biomaterials development of a tumor-specific delivery system for the treatment of peritoneal carcinomatosis. We demonstrate that after intraperitoneal administration, pH-sensitive polymeric vesicles…
An homing peptide that targets injured brain tissue highlighted in Nature Reviews
Written on Monday, 18 July 2016 13:37This peptide can guide drugs and imaging agents to acute brain injuries and result in enhanced benefit. The peptide was identified by Aman Mann and…
Hyaluronan-binding peptide for targeting peritoneal carcinomatosis
Written on Monday, 12 June 2017 16:29Ikemoto H, Lingasamy P, Anton Willmore AM, Hunt H, Kurm K, Tammik O, Scodeller P, Simón-Gracia L, Kotamraju VR, Lowy AM, Sugahara KN, Teesalu T.…
Tumor-Penetrating Nanosystem Strongly Suppresses Breast Tumor Growth
Written on Monday, 12 June 2017 16:21Sharma S, Kotamraju VR, Mölder T, Tobi A, Teesalu T, Ruoslahti E. Nano Lett. 2017 Mar 8;17(3):1356-1364. doi: 10.1021/acs.nanolett.6b03815. Epub 2017 Feb 17. Tumor-Penetrating Nanosystem…
JuneLinear TT1 peptide-coupled FAM-labeled iron oxide nanoparticles home to blood vessels of subcutaneous U87 tumor xenograftLinear TT1 peptide-coupled FAM-labeled iron oxide nanoparticles (green) home to blood vessels (red) of subcutaneous U87 tumor xenograft. Cell nuclei are stained with DAPI (blue). Scale bar – 50 µm.…
MayDark-field image of silver nanoparticles with RPARPAR-MMAE-AgNP internalized by PPC-1 prostate cancer cellsDark-field image of silver nanoparticles with cytotoxic drug monomethyl auristatin E and RPARPAR peptide (RPARPAR-MMAE-AgNP) internalized by PPC-1 prostate cancer cells after 1 h incubation. Extracellular fraction of AgNPs was…
AprilPET-CT image of breast tumor bearing mouse i.v. injected with iRGD targeted nanoparticlesPET-CT scan was acquired 24 hours after sample administration. The radiolabeled iRGD-nanoparticles accumulates in breast tumor (white arrow). Authors: Lorena Simón Gracia and Pablo Scodeller