The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
New nanoparticles for detection of small breast tumors with PET imaging reported in Oncotarget
Written on Thursday, 24 May 2018 12:52We have designed new nanoparticles that detect small breast tumors using the clinically used medical imaging modality Positron Emission Tomography (PET). The particles are polymeric…
Tambet Teesalu’s translational work recognized by the University of Tartu
Written on Thursday, 24 May 2018 12:50The translational work at the Lab of Cancer Biology in 2017 was recognized by University of Tartu by awarding the head of the laboratory Tambet…
Review on affinity targeting of peritoneal carcinomatosis
Written on Friday, 18 May 2018 09:11Lorena, Hedi and Tambet from LCB published a review entitled „Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides“ in Molecules (2018, 23(5), 1190; https://doi.org/10.3390/molecules23051190). The review…
Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides
Written on Thursday, 24 May 2018 14:05Simón-Gracia L, Hunt H, Teesalu T..Molecules. 2018 May 16;23(5). pii: E1190. doi: 10.3390/molecules23051190. Review.Read more...
Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice
Written on Thursday, 24 May 2018 14:02Simón-Gracia L, Scodeller P, Fuentes SS, Vallejo VG, Ríos X, San Sebastián E, Sidorenko V, Di Silvio D, Suck M, De Lorenzi F, Rizzo LY,…Read more...
JanuaryHigh infiltration of CD206+ cells in human breast tumorsImmunohistochemical staining of human CD206 (brown) with nuclear counterstain (Hematoxilin, in dark blue). Authors: Anni Lepland and Pablo Scodeller.
DecemberLong persistence of an M2 TAM internalizing peptide in breast tumorsAn M2 macrophage binding peptide (green) identified in our lab using phage display remains inside M2 TAMs (red) at least 24 hours after systemic administration in a mouse model of…
JuneLinear TT1 peptide-coupled FAM-labeled iron oxide nanoparticles home to blood vessels of subcutaneous U87 tumor xenograftLinear TT1 peptide-coupled FAM-labeled iron oxide nanoparticles (green) home to blood vessels (red) of subcutaneous U87 tumor xenograft. Cell nuclei are stained with DAPI (blue). Scale bar – 50 µm.…