The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
iRGD-targeted polymersomes for enhanced intraperitoneal chemotherapy
Written on Tuesday, 09 August 2016 09:36We report in Biomaterials development of a tumor-specific delivery system for the treatment of peritoneal carcinomatosis. We demonstrate that after intraperitoneal administration, pH-sensitive polymeric vesicles…
An homing peptide that targets injured brain tissue highlighted in Nature Reviews
Written on Monday, 18 July 2016 13:37This peptide can guide drugs and imaging agents to acute brain injuries and result in enhanced benefit. The peptide was identified by Aman Mann and…
Our ratiometric silver nanoparticles featured on the cover of Nanoscale
Written on Tuesday, 03 May 2016 13:33Our article titled "Targeted Silver Nanoparticles for Ratiometric Cell Phenotyping" is well received. It has been chosen to the cover of the May issue of…
iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes
Written on Monday, 08 August 2016 14:49Simon-Gracia L, Hunt H, Scodeller P, Gaitzsch J, Kotamraju VR, Sugahara KN, Tammik O, Ruoslahti E, Battaglia G, Teesalu T Biomaterials. 2016 Jul 20;104:247-257. doi: 10.1016/j.biomaterials.2016.07.023.…
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries
Written on Wednesday, 29 June 2016 10:53Aman P. Mann, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Ester Kwon, Gary B. Braun, Tarmo Mölder, Zhi-gang She, Venkata Ramana Kotamraju, Barbara Ranscht, Stan rajewski,…
JanuaryInfiltrating CD206-positive macrophages in peritoneal MKN45P gastric carcinoma xenograftInfiltrating CD206-positive macrophages in peritoneal MKN45P gastric carcinoma xenograft.Author: Hedi Hunt, MSc.
DecemberTransmission electron microscopy image of a dextran coated iron oxide nanoworm structureRed color was applied with photo editing. Merry Christmas! Author: Allan Tobi, MSc
NovemberGlih27 peptide conjugated with iron oxide nanoworms (green) in mouse brain with VEGF KO glioblastomaThe nanoworms with peptide home to ependymal cells. Red – blood vessels, blue – DAPI. Author: Pille Säälik, PhD