The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
iRGD-targeted polymersomes for enhanced intraperitoneal chemotherapy
Written on Tuesday, 09 August 2016 09:36We report in Biomaterials development of a tumor-specific delivery system for the treatment of peritoneal carcinomatosis. We demonstrate that after intraperitoneal administration, pH-sensitive polymeric vesicles…
An homing peptide that targets injured brain tissue highlighted in Nature Reviews
Written on Monday, 18 July 2016 13:37This peptide can guide drugs and imaging agents to acute brain injuries and result in enhanced benefit. The peptide was identified by Aman Mann and…
Our ratiometric silver nanoparticles featured on the cover of Nanoscale
Written on Tuesday, 03 May 2016 13:33Our article titled "Targeted Silver Nanoparticles for Ratiometric Cell Phenotyping" is well received. It has been chosen to the cover of the May issue of…
iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes
Written on Monday, 08 August 2016 14:49Simon-Gracia L, Hunt H, Scodeller P, Gaitzsch J, Kotamraju VR, Sugahara KN, Tammik O, Ruoslahti E, Battaglia G, Teesalu T Biomaterials. 2016 Jul 20;104:247-257. doi: 10.1016/j.biomaterials.2016.07.023.…
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries
Written on Wednesday, 29 June 2016 10:53Aman P. Mann, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Ester Kwon, Gary B. Braun, Tarmo Mölder, Zhi-gang She, Venkata Ramana Kotamraju, Barbara Ranscht, Stan rajewski,…
OctoberTargeting-polymeric nanoparticles are internalized in MCF-7 and U87 spheroidsFluorescein-labeled polymeric nanoparticles functionalized with a targeting peptide (in green) are internalized into MCF-7 (from breast tumor) and U87 (from glioblastoma) spheroids that express the NRP-1 receptor (in red). The…
SeptemberAn infiltratively growing patient-derived mouse glioma xenograft P21 developed in our lab expresses nestin (green) and Ki67 (red) positive cells.Cell nuclei are stained with DAPI (blue). Author: Pille Säälik, PhD
AugustIntravenously injected "UNO" peptide enters protumoral macrophagesAngiogenic glioblastoma, WTGBM. Microscope: Olympus FV1200MPE-BX61WI confocal microscope at 20X magnification Green: peptide, Red: tumor associated macrophages, blue: cell nuclei. Authors: Pablo Scodeller PhD, Pille Säälik PhD