The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
A small peptide identified with phage display highlighted in Nature Reviews
Written on Monday, 18 July 2016 13:37This peptide can guide drugs and imaging agents to acute brain injuries and result in enhanced benefit. The peptide was identified by Aman Mann and…
Our ratiometric silver nanoparticles featured on the cover of Nanoscale
Written on Tuesday, 03 May 2016 13:33Our article titled "Targeted Silver Nanoparticles for Ratiometric Cell Phenotyping" is well received. It has been chosen to the cover of the May issue of…
Kadri Toome's image of spheroids was shared by Molecular Probes in Facebook
Written on Wednesday, 06 January 2016 10:22Our work reaches Social Media. Few days ago Molecular Probes (Thermo Fisher Scientific) shared our image U87 cell line spheroids taking up RPARPAR-AgNPs (image of the…
A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries
Written on Wednesday, 29 June 2016 10:53Aman P. Mann, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Ester Kwon, Gary B. Braun, Tarmo Mölder, Zhi-gang She, Venkata Ramana Kotamraju, Barbara Ranscht, Stan rajewski,…
Tumor-homing peptides as tools for targeted delivery of payloads to the placenta
Written on Monday, 09 May 2016 13:52Kind A, Ndifon C, Lui S, Widdows K, Kotamraju VR, Agemy L, Teesalu T, Glazier JD, Cellesi F, Tireli N, Aplin JD, Ruoslahti E, Harris…
JulyNanoparticles homing to breast tumorLeft: electron microscopy images of polymeric nanoparticles targeted with tumor penetrating peptide loaded with cancer drug. Right: Confocal microscopy pictures of tumor, kidney, and liver tissue sections of mouse bearing…
JuneTwo-photon image of blood vessels with Evans Blue after tail vein injectionDetection with multiphoton microscope Olympus FV1200MPE-BX61WI and Spectra-Physics MaiTai DeepSee IR laser. Objective: XLPLN25xW-MP (NA 1.05; Olympus). Excitation: 950nm. Author: Maarja Haugas, PhD
MayHollow gold-silver nanospheresHollow gold-silver nanospheres imaged with a TEM at 160 000x magnification. Author: Anne-Mari Anton Willmore, MSc