The mission of the Cancer Biology Laboratory is to develop smart cancer therapeutics with increased potency and decreased side effects.
We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs, biologicals, and nanoparticles into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue.
Our ratiometric silver nanoparticles featured on the cover of Nanoscale
Written on Tuesday, 03 May 2016 13:33Our article titled "Targeted Silver Nanoparticles for Ratiometric Cell Phenotyping" is well received. It has been chosen to the cover of the May issue of…
Kadri Toome's image of spheroids was shared by Molecular Probes in Facebook
Written on Wednesday, 06 January 2016 10:22Our work reaches Social Media. Few days ago Molecular Probes (Thermo Fisher Scientific) shared our image U87 cell line spheroids taking up RPARPAR-AgNPs (image of the…
Multiphoton microscope at the Lab of Cancer Biology
Written on Monday, 09 November 2015 13:43We are excited to announce that Olympus FV1200MPE-BX61WI multiphoton microscope of the Lab of Cancer Biology is installed and fully operational. The microscope is optimized…
Tumor-homing peptides as tools for targeted delivery of payloads to the placenta
Written on Monday, 09 May 2016 13:52Kind A, Ndifon C, Lui S, Widdows K, Kotamraju VR, Agemy L, Teesalu T, Glazier JD, Cellesi F, Tireli N, Aplin JD, Ruoslahti E, Harris…
Urokinase-controlled tumor penetrating peptide
Written on Tuesday, 26 April 2016 15:48Braun GB, Sugahara KN, Yu OM, Kotamraju VR, Mölder T, Lowy AM, Ruoslahti E, Teesalu T J Control Release. 2016 Apr 19. pii: S0168-3659(16)30240-1. doi: 10.1016/j.jconrel.2016.04.027.…
MayHollow gold-silver nanospheresHollow gold-silver nanospheres imaged with a TEM at 160 000x magnification. Author: Anne-Mari Anton Willmore, MSc
AprilThe "UNO" peptide recognizes circulating tumor associated macrophagesMouse model of metastatic human gastric cancer, MKN45-P. Microscope: Olympus FV1200MPE-BX61WI confocal microscope at 20X magnification Green: peptide, Red: tumor associated macrophages, blue: cell nuclei. Author: Pablo Scodeller, PhD
MarchTT1-FAM-IONWWT GBM intracranial glioma-bearing mouse was injected with 7,5 mg /kg TT1-FAM-iron oxide nanoworms. After 5 hours of circulation the mouse was perfused and FAM fluorescence was detected by illumatool.…